1 – Caism – UNICAMP2 – UNICAMP
Objectives: To determine the differences in the evolution of patients with sporadic breast cancer (SBC) according to neutrophil-lymphocyte ratio (NLR). Methods: Survival was evaluated in a retrospective cohort from 419 women’s medical records who joined as new cases of SBC in single academic institution, from January 2003 to August 2007. Frequencies, means and standard deviations of the variables were calculated, and statistical analysis were performed with the R Environment for Statistical Computing (R Project), with p=0.05 considered as significant, and confidence intervals (CI) set at 95%. Multivariate regression model was applied to adjust the p-values, and the relationships between clinical and epidemiological features with NLR were evaluated by univariate and multivariate analysis. Five-year Kaplan-Meyer survival curves were tabulated and the survival differences were evaluated by log-rank test. Results: 86% of patients were caucasian, median age were 54 years, in 42.2% of cases the occurrence of SBC were premenopausal, 66.3% of women presented BMI higher than 25, 70% of histological types were non-special breast carcinoma, 53.2% presented stages I and II, and 26% of tumors were hormonal receptors negative. Obesity is related with the NLR index above 3.0 (p=0.046). In multivariate analysis, there was a statistically significant difference in survival of patients with NLR in cutoff=3.0 (p=0.031). Conclusion: Pre-treatment NLR above 3.0 was associated with lower survival in patients with SBC, and may have a role as an independent predictor, similar to what has been shown for other solid tumors.Key words: Neutrophil-lymphocyte ratio, sporadic breast cancer, prognostic factor, inflammatory response.
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