SERUM LEVELS OF 25(OH)D IN WOMEN USING AROMATASE INHIBITORS AND THE ASSOCIATION BETWEEN BODY COMPOSITION AND FUNCTIONAL CAPACITY

Kamila Pires Carvalho (CARVALHO, K.P.) (Universidade Federal de Uberlândia), Mariana Tavares Miranda Lima (LIMA, M.T.M.) (Universidade Federal de Uberlândia), Fernanda Silva Mazzutti (MAZZUTTI, F.S.) (Universidade Federal de Uberlândia), Carlos Eduardo Pa

Universidade Federal de UberlândiaTo assess the association between serum 25(OH)D levels, body composition parameters and functional capacity in women using aromatase inhibitors (AI). A cross-sectional study with 89 women with breast cancer on endocrine therapy with AI. The Health Assessment Questionnaire (HAQ) was applied and weight, height, waist circumference (WC) and body mass index (BMI) were evaluated. Bioelectrical impedance was used to calculate the fat free mass (FFM), body fat (BF), and body fat percentage (%BF). Serum levels of 25(OH)D were evaluated by the chemiluminescence method, and serum levels ≥30ng/ml were considered adequate. Descriptive analysis was performed using frequency, median and 25th and 75th percentiles. Mann-Whitney and Kruskal-Wallis tests were used to compare the variables. The significance level adopted was 5% and statistical analyzes were performed in SPPSS 21.0 software. Serum levels of 25(OH)D were considered adequate in 60.7% (n=54) and inadequate in 39.3% (n=35). Blood collection occurred mainly in the summer (49.4%, n=44), followed by autumn (33.7%, n=30) and winter (16.9%. n=15). There was a significant difference between serum levels 25(OH)D and the season of the year (p=0.02). Although women with serum levels of 25(OH)D ?30 ng/ml had weight [69.0 (60.2-76.5), 66.7 (60.0-75.9), p = 0.513]; BMI [28.7 (25.4-31.4), 28.0 (25.3-31.6), p=0.807]; BF [29.1 (19.6-36.6), 23.1 (17.6-34.6), p=0.465] and %BF [43.1 (30.1-45.6), 33.4 (29.0-45.1), p = 0.429] higher than women with serum levels ≥30 ng/ml, these differences were not significant. Regarding functional capacity, the women did not differ in the levels of 25(OH)D [0.9 (0.5-1.8), 0.9 (0.4-1.3), p = 0.668]. Serum 25(OH)D levels in women using aromatase inhibitors were adquate, with no difference between vitamin D levels, body composition and functional capacity.Aromatase Inhibitors, Body Composition, Breast neoplasm, Functional Capacity.