DEEP VEIN THROMBOSIS INCIDENCE IN WOMEN DIAGNOSED WITH BREAST CANCER IN BRAZIL BETWEEN 2007-2009

Daniele Medeiros Torres, Sabrina da Silva Santos, Flávia Oliveira Macedo, Marianna Brito de Araújo Lou, Rejane Medeiros Costa, Érica Alves Nogueria Fabro, Laís Goulart Cruz Baldanza, Rosalina Jorge Koifman

Institution: Instituto Nacional de Câncer – INCA/HCIII

“Aims: The aim of this study was to evaluate the incidence of deep vein thrombosis (DVT) in the cohort of women diagnosed with breast cancer at the Brazilian National Cancer Institute (INCA), between 2007-2009.Methods: A retrospective observational study in a hospital cohort of 4,413 women diagnosed with breast cancer, between 2007-2009, and followed by 60 months.The data bases were the hospital registry of INCA Cancer Hospital III and the first episode of deep venous thrombosis was determined by Ultrasound Dopller. For descriptive analysis, continuous variables were expressed as means and standard deviation and categorical variables were as percentages. The differences between them were analyzed using the chi-square test. Cumulative incidence analyzes were performed using the survival functions by Kaplan-Meier method.Results: The conditional probability of developing DVT after diagnosis of breast cancer was 2.5% (n = 102) at 60 months of follow-up. By comparing the groups with and without DVT diagnosis, considering the clinical in 4,413 women with breast cancer, 55.3% of them were advanced stage (³IIB) at the time of diagnosis and there was a statistically significant difference in the proportion of women diagnosed in these stages in the group diagnosed with DVT (73.5%), compared to those without DVT diagnosis (54.8%). Regarding the treatments for breast cancer, there was a statistically significant difference between the proportions of surgery and chemotherapy, with a higher proportion of women in the group who developed DVT held chemotherapy (86.1%) than the group not presented DVT (62.7%) and it was observed that a higher proportion of women in the group who developed DVT died (52.9%) than the group with no DVT (26, 3%), this was a statistically significant result.Conclusions: The incidence of DVT in this cohort of women diagnosed with breast cancer was low and remained relatively constant during the study time.

Keywords: Breast cancer; Deep vein thrombosis; Cohort studies.