AXILLARY SURGERY IN BREAST CANCER CLINICAL STAGE T1-T2N0M0: SURVIVAL IN A HOSPITAL COHORT OF WOMEN IN RIO DE JANEIRO.

Flávia O. Macedo, Anke Bergmann, Erica A. N. Fabro, Daniele M. Torres, Cristiane M. Carvalho, Maria Justina P. Ribeiro, Juliana Flávia de O. T. de Oliveira, Ilce F. da Silva

Institution: Instituto Nacional de Câncer -INCA/HCIII

“Objectives: To determine the overall survival (OS) and disease-free survival (DFS) in women with breast cancer classification T1 and T2N0M0 diagnosed and treated at the National Cancer Institute (INCA) between 2007-2009 according to axillary surgery (sentinel lymph node biopsy – SLNB and axillary lymphadenectomy – AL). Methods: Observational study of a cohort of 933 women with clinical diagnosis T1-T2N0M0 treated at Cancer Hospital III of the National Cancer Institute (HC-III/INCA) in 2007-2009, and followed by a period of 60 months. Data collection was based on analysis of the Hospital Registry Cancer, the physical and/or electronic records of patients – HCIII/INCA and clinical evaluation form the Physical Therapy Service of the HC-III/INCA. Among the evaluated information included sociodemographic, clinical, lifestyle habits, implemented treatments and outcome variables (disease status and vital status). Results: The cohort was divided into 683 women undergoing SLNB, 144 to SLNB followed by AL and 106 patients received AL directly. After 5 years of follow-up was observed OS (96,2% vs 93,4%; HR: 0,72; IC95% 0,37-1,40) e DFS (93,7% vs 92,3%; HR: 0,95; IC95% 0,53 – 1,70) similar among patients undergoing SLNB compared to those receiving AL, regardless of age and staging. In patients with micrometastases, OS (93,3% vs 87,5%) and DFS (100% vs 90,7%) were higher in women who underwent SLNB compared those receiving SLNB followed by AL, but without statistical significance. Conclusion: In patients with clinical stage T1-T2N0M0, those who underwent BLS showed OS and DFS at 60 months statistically similar to those submitted to AL after SLNB and AL directly. In women with lymph node micrometastases, there were no statistically significant differences in OS and DFS at 60 months in women undergoing BLS compared to those submitted to BLS followed by LA.

Keywords: Breast Cancer; Biopsy of the Sentinel Lymph Node; Axillary Lymphadenectomy; Global Survival; Disease-free Survival.”

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