Evaluate the characteristics of patients with triple negative (TN) submitted to neoadjuvant chemotherapy attended at the Dr Arnaldo Vieira de Carvalho Cancer Institute (ICAVC) from 2006 to 2012.
Prognostic evaluation of patients with triple negative immunophenotype, submitted to neoadjuvant chemotherapy.
Fábio F. O. Rodrigues, Etiénne A. Bastos, Laís A. Inaba, Eveline A. Silva, Rodrigo M. Silva, Carlos E. Fristachi
Instituto do Câncer Doutor Arnaldo Vieira de Carvalho
Objectives: Evaluate the characteristics of patients with triple negative (TN) submitted to neoadjuvant chemotherapy attended at the Dr Arnaldo Vieira de Carvalho Cancer Institute (ICAVC) from 2006 to 2012. Methods: A longitudinal study was performed, descriptive type, retrospective, of patients with invasive breast carcinoma attended at ICAVC in Sao Paulo; data were analyzed on the data base of Microsoft Excel@. Results: Were evaluated 267 patients, among them, 24 (9%) presented TN breast neoplasm by the immunohistochemical study; 21 % of them underwent neoadjuvant chemotherapy, having as main regimens the association of anthracycline and taxane; 4% presented pathological complete response (pCR) and 29% evolved with distant metastasis; being the disease free survival and mean global survival of 3 years calculed with Kaplan Meier. Conclusion: With this study, we observed 27% of triple negative tumors that, differently from the literature, presented the small complete pathological responde index of only 4%.