BREAST CANCER IN VERY YOUNG WOMEN

Délio Marques conde, Larissa Cunha Morais, Cristiane Fagundes Pacheco, Rogério Bizinoto Ferreira, Érika Pereira de Sousa e Silva, Sebastião Alves Pinto, Edson Zangiacomi Martinez

Institution: Hospital Materno Infantil

“Objectives: to investigate the disease-free survival (DFS), the relapse-free fraction (RFF) and the prognostic factors of very young women with breast cancer. Methods: we conducted a retrospective study in which they included 41 breast cancer women under 35 years old. The clinical and pathological features, and factors related to treatment were investigated. We used the Kaplan-Meier method to estimate the DFS. Results: The DFS was 74.7% in 48 months. DFS was significantly higher in women with tumors up to 2 cm vs > 2 cm (84.3×69.3, p = 0.04), no luminal subtype vs luminal (76.9×68.6, p <0.01) and underwent mastectomy vs breast-conserving treatment (75.3×72.9, p = 0.03). The RFF was significantly higher for women over 30 years of age vs up to 30 years (82.7×28.7, p = 00.2), multifocal tumors (p <0.01), tumors up to 2 cm (p <0.01), histological grade I/II vs III (68.2×0, p <0.01), stages I/II vs III (60.1×0, p <0.01). Conclusions: Our data suggest that within the group of young women with breast cancer there is a subgroup of younger women, those under 30 years, with worse prognosis. Future studies with larger samples may help to elucidate this aspect.Key words: breast cancer, prognostic factors, very young women”

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