PROFILE OF WOMEN ATTENDED AT A BRAZILIAN SERVICE IN HIGH RISK FOR BREAST CANCER

Tamara Pinto de Oliveira Araujo, Gabriel Yaemon Ikejiri, Patrícia Kajikawa, Natalie Rios Almeida, Nicoli Serquiz Azevedo, Fernanda Madrassi Campora, Renato Zocchio Torresan, Cesar Cabello dos Santos

“Introduction: Breast cancer is the most common malignant neoplasia affecting women in Brazil and the whole world. However, among the general population, there’s a portion more likely to develop this kind of cancer, deserving special attention concerning primary and secondary prevention. The definition of high risk for breast cancer varies between entities around the world, but all of them converge to ensuring special attention to this specific population.Objectives: Describe the population of a high risk for breast cancer service; calculate its risk for BRCA1/2 mutation and cancer risk by Tyrer-Cuzick and Gail methods.Methods: Transversal analysis of women cohort followed in a high risk for breast cancer specialized service through an applied quiz and then calculate the risks by Tyrer-Cuzick and Gail methods.Results: Ninety eight patients were included, with median age of 41,7 years. Of all patients, 11,3% had any kind of breast cancer precursor lesion, and 79,6% had at least one first degree relative with breast cancer. The median lifetime risk calculated by Tyrer-Cuzick and Gail were respectively 29,9% and 20,4%. The estimated median prevalence of BRCA1 and 2 mutation calculated by Tyrer-Cuzick was respectively 5% and 3,8%. Of these patients, 53,8% had their breasts described as dense or heterogeneously dense. Nearly 63,5% of patients were submitted to mammary ultrasound and 64,6% to periodic mammography. Routine pelvic ultrasound was performed in 29,5% of patients. A minority of patients (5%) were submitted to periodic magnetic resonance imaging of the breast.Conclusion: The high risk population need a specialized management. Screening and prevention strategies must be intensively directed to this group. The majority of patients followed in our service had a high vital risk estimated and the use of risk calculation methods is essencial for identifying these patients and setting their follow-up.

Key words: high risk, breast cancer, risk calculation